1,1,1,2-Tetrafluoroethane (also known as R-134a,HFC-134a) is a hydrofluorocarbon (HFC) and haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential and a lower 100-year global warming potential (1,430, compared to R-12's GWP of 10,900).It has the formula CF3CH2F and a boiling point of −26.3 °C (−15.34 °F) at atmospheric pressure. A phaseout and transition to HFO-1234yf and other refrigerants, with GWPs similar to CO2, began in 2012 within the automotive market.

R134A is a non-flammable gas used primarily as a "high-temperature" refrigerant for domestic refrigeration and automobile air conditioners. Other common uses include plastic foam blowing, as a cleaning solvent, a propellant for the delivery of pharmaceuticals (e.g. bronchodilators), wine cork removers, gas dusters ("canned air"), and in air driers for removing the moisture from compressed air.

Refrigerant cylinders are pressurized containers and should be stored away from fire and heat sources and avoid direct sunlight. They are usually stored in a cool, dry and ventilated warehouse.They should be loaded and unloaded gently during transportation to prevent damage to the cylinders and accessories such as valves.

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